PLEASE NOTE: Due to COVID-19, we regret there may be a significant delay in the delivery of international orders. We appreciate your patience as we adjust to the challenges presented by the current health crisis. Learn more >

PLEASE NOTE: Due to COVID-19, we regret there may be a significant delay in the delivery of international orders. We appreciate your patience as we adjust to the challenges presented by the current health crisis. Learn more >

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Histamine Digest with DAO2
Omne Diem Histamine Digest Supplement Facts
Histamine Digest
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Histamine Digest with DAO 60 Capsules

$59.95 — or subscribe and save 5%

Omne Diem Histamine Digest supplies Diamine Oxidase (DAO), the enzyme that neutralizes histamine in the digestive tract.* Taking Omne Diem Histamine Digest prior to consuming high histamine foods and beverages defends against digestive histamine sensitivity and the occurrence of accompanying reactions.*

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Description
Histamine Digest feast

Histamine Intolerance is real. Omne Diem™ Histamine Digest can help. 

Omne Diem Histamine Digest supplies Diamine Oxidase (DAO), the enzyme that neutralizes histamine in the digestive tract.* Taking Omne Diem Histamine Digest prior to consuming high histamine foods and beverages defends against digestive histamine sensitivity and the occurrence of accompanying reactions.*

Natural

Our DAO is a natural enzyme-rich protein extract from porcine kidney that is delivered to the small intestine.

Convenient

DAO promotes histamine degradation within 20 min after intake.

Safe

DAO is not absorbed into the body and no adverse events have been recorded with DAO supplementation.

What is Histamine?

Histamine is a biogenic amine present in our bodies and in our food supply. Biogenic amines are found in everything from dairy products and meats to fruits, vegetables and grains. Processes that result in the microbial alteration of foods — such as aging (meat), fermentation (wine, spirits, cheese), and package processing (prepared packed foods) — can increase the levels of histamine and other biogenic amines in foods and beverages.

Omne Diem™ Histamine Digest supplies Diamine Oxidase, the enzyme that neutralizes dietary histamine in the digestive tract. Taking Omne Diem™ Histamine Digest prior to consuming high histamine foods and beverages defends against digestive histamine sensitivity to help reduce the occurrence of histamine intolerance.*

Histamine

Allergy or Intolerance?

While the symptoms of Histamine Intolerance (HIT) may mimic allergic reactions, HIT is not a classical food allergy. Rather, research suggests that HIT is mediated by a deficiency in levels and/or activity of the Diamine Oxidase enzyme.

Allergy – An immune system response to a specific allergenic substance. Symptoms can appear quickly with very little exposure.

Intolerance – An "allergy-like" reaction that does not involve an immunological response. Reactions can take time to appear and increase upon level of exposure.

Allergy vs Intolerance

Symptoms of Histamine Intolerance

While the symptoms of Histamine Intolerance (HIT) may mimic allergic reactions, HIT is not a classical food allergy. Rather, research suggests that HIT is mediated by a deficiency in levels and/or activity of the Diamine Oxidase enzyme. Reactions are variable, seem unrelated and are widespread. Common reactions include:

  • Vasodilation (flushing/reddening)
  • Hypotension/Tachycardia
  • Stuffy, Runny Nose/Sneezing
  • Swelling or Red, Watery Eyes
  • Headache or Migraine
  • Diarrhea, Cramps, Bloating
  • Feelings of Anxiety
  • Urticaria (hives)

Prevalence

Indication Percentage of Western Population
Lactose Intolerance 10-30%
Fructose Malabsorption 33%
Food Allergy 3-5%
Histamine Intolerance 2-5%
Celiac Disease 0.5%
Fructose Intolerance <.01%

Solution - Digestive Enzyme: Diamine Oxidase (DAO)*

• Neutralizes histamine in the gut*

• Non-systemic, no drug — nutrient interactions, natural kidney extract

8% of people worldwide are affected by histamine intolerance†

Intolerance occurs when the histamine levels in the body get too high or can’t be broken down properly — when histamine levels exceed the amount of diamine oxidase enzyme (DAO) available for degradation.

How Histamine Digest Works

Diamine Oxidase (DAO) is responsible for the degredation of biogenic amines ingested with food (exogenous histamine). DAO is active in the ilium and jejunum of the small intestine. It is also found concentrated in the kidney, thymus and placenta. When histamine levels in the digestive tract become excessive, DAO breaks down the excess. When there is a deficiency of available DAO or DAO activity is blocked, reactions can occur. Omne Diem Histamine Digest supplies natural, active supplemental DAO to help neutralize excess histamine.*

Causes of Histamine Intolerance

Imbalance between histamine and the degrading enzyme Diamine Oxidase (DAO)

Cause of histamine intolerance
Histamine Digest

Histamine-Rich Foods

  • Chocolate
  • Cheese (all types, especially aged)
  • Sauerkraut
  • Tuna
  • Aged, cured, processed and fermented meats (pepperoni, sausage, bacon)
  • Tomatoes/Ketchup
  • Vinegar (all types)
  • Alcoholic beverages
  • Shellfish
  • Avocado
  • Bananas
  • Eggplant
Histamine Beer

Histamine Liberators

  • Berries (especially strawberries)
  • Alcoholic Beverages
  • Milk and dairy products
  • Citrus fruits
  • Bananas
  • Chocolate
  • Shellfish
Medication

DAO Enzyme-Inhibiting Drugs

  • Acemetacin
  • Acetylcysteine
  • Adalimumab (Humaira)
  • Amitriptyline
  • Antihistamines
  • Aspirin
  • Diazapam
  • Duloxetine (Cymbalta)
  • Etanercept (Enbrel)
  • Fluoxetine (Prozac)
  • Haloperidol
  • Ibuprofen
  • Neomycin
  • Propranolol
  • Sertraline (Zoloft)
  • Venlafaxine
  • Verapamil

Triple-threat

Alcoholic beverages present a “triple-threat” to histamine levels by: 

  1. 1. Introducing excess histamine levels
  2. 2. Liberating histamine 
  3. 3. Blocking the activity of DAO in the gastrointestinal tract.

DOES NOT CONTAIN: Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Additional information
Weight 1.9 oz
Dimensions 2.06 × 2.06 × 2.94 in
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Shipping & Delivery

We are dedicated to making sure your experience ordering from Diem Direct is always great. Below are the shipping methods we offer, so you can choose which is right for you and know when to expect your order. 

United States shipping methods and delivery ETAs: 

  • Standard shipping (via USPS): 7 business days after the item ships.
  • UPS Ground shipping: 3-5 business days after the item ships.
  • UPS Next Day/2nd Day Air: guaranteed same day shipment if your order is placed on a business day by 11am, Central Standard Time; all Air orders entered after this time will ship the next business day.
  • Your order will generally be shipped the same day if your order is placed by 11am, Central Standard Time. If your order is placed after that time, or on a non-business day, your order will ship the next business day. No C.O.D. will be accepted.
  • Business Days are defined as Monday through Friday.

International shipping methods and delivery ETAs: 

  • UPS Worldwide Expedited: 7-10 business days after the item ships.
  • USPS First Class International (North America only): up to 20 business days after the item ships.
  • Your order will generally be shipped the same day if your is placed by 11am Central Standard Time. If your order is placed after that time, or on a non-business day, your order will ship the next business day. No C.O.D. will be accepted.
  • Delivery time frames do not include any time the package may be in possession by your local Customs bureau, only the time in transit by the carrier.
  • Business Days are defined as Monday through Friday.

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any diseases.

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